How T-cells navigate the rough-and-tumble environment of the bloodstream

Helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, scientists show that immature T cells lack these protrusions but that maturing T-cells switch on a gene expression program to create material to construct them. Source: Feed4

Neuroscientists shed light on causes of postpartum depression using new research model

Postpartum depression strikes nearly one in five new mothers. Stress is a significant risk factor for this complex condition. Neuroscientists have generated a novel preclinical model of postpartum depression and demonstrated involvement of the hypothalamic-pituitary-adrenal axis (the neuroendocrine system that mediates physiological response to stress and is normally suppressed during and after pregnancy). These findings […]

Pain-free skin patch responds to sugar levels for management of type 2 diabetes

Researchers have devised a biochemically formulated patch of dissolvable microneedles for the treatment of type 2 diabetes. The biochemical formula of mineralized compounds in the patch responds to blood chemistry to manage glucose automatically. In a proof-of-concept study performed with mice, the researchers showed that the chemicals interact in the bloodstream to regulate blood sugar […]