Metastatic cancer cells modify bone remodeling with small RNA secretion in bone metastasis

Prostate cancer frequently metastasizes and spreads to bone, causing severe pain, fractures, and other complications. The mechanisms that allow cancer cells to modify bone remodeling are incompletely understood. Researchers have now identified a microRNA, miR-940, that is abundant in exosomes secreted by prostate cancer cells and can trigger bone-forming lesions in mice. The findings indicate […]

How a genetic mutation can interfere with the powerhouses of cells

Scientists have identified the molecular consequences of a previously undefined genetic mutation. This mutation interferes with the functioning of the mitochondria, known as the powerhouses of cells. It usually occurs following what would normally be a harmless infection in early childhood, leading to a severe disease and subsequently to the brain no longer being able […]