'Rewired' cells show promise for targeted cancer therapy

A major challenge in truly targeted cancer therapy is cancer’s suppression of the immune system. Synthetic biologists now have developed a general method for ‘rewiring’ immune cells to flip this action around. When cancer is present, molecules secreted at tumor sites render many immune cells inactive. The researchers genetically engineered human immune cells to sense the tumor-derived molecules in the immediate environment and to respond by becoming more active, not less.
Source: Feed4

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