With cancer genome sequencing, be your own control

When a researcher found more than 1,000 genetic translocations in her mouse model of B cell lymphoma, she assumed her lab had made a mistake. To rule out experimental technique as the cause of the way-more-than-expected genomic alterations, the lab sequenced three different types of cells from “wildtype” mice – effectively the kind that might move into your garage in bad weather. Like the lymphoma cells before them, the cells from wildtype mice also had over a 1,000 translocations.
Source: Feed4

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